Pub. Date : 2018 Mar 5
PMID : 29544563
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Sorafenib induces renal cell carcinoma apoptosis via upregulating activating transcription factor 4. | Sorafenib | activating transcription factor 4 | Homo sapiens |
| 2 | However, whether sorafenib improves renal cell carcinoma (RCC) through activating transcription factor 4 (ATF4) has never been explored. | Sorafenib | activating transcription factor 4 | Homo sapiens |
| 3 | However, whether sorafenib improves renal cell carcinoma (RCC) through activating transcription factor 4 (ATF4) has never been explored. | Sorafenib | activating transcription factor 4 | Homo sapiens |
| 4 | Furthermore, sorafenib is demonstrated to enhance the mRNA and protein levels of ATF4. | Sorafenib | activating transcription factor 4 | Homo sapiens |
| 5 | More importantly, silencing of ATF4 could largely abolish sorafenib-induced upregulation of CHOP and PUMA in ACHN cells. | Sorafenib | activating transcription factor 4 | Homo sapiens |
| 6 | Meanwhile, sorafenib-induced cell apoptosis may be dependent on the activation of ATF4 since knockdown of ATF4 partially reversed sorafenib-induced ACHN cell apoptosis. | Sorafenib | activating transcription factor 4 | Homo sapiens |
| 7 | Meanwhile, sorafenib-induced cell apoptosis may be dependent on the activation of ATF4 since knockdown of ATF4 partially reversed sorafenib-induced ACHN cell apoptosis. | Sorafenib | activating transcription factor 4 | Homo sapiens |
| 8 | Meanwhile, sorafenib-induced cell apoptosis may be dependent on the activation of ATF4 since knockdown of ATF4 partially reversed sorafenib-induced ACHN cell apoptosis. | Sorafenib | activating transcription factor 4 | Homo sapiens |
| 9 | Meanwhile, sorafenib-induced cell apoptosis may be dependent on the activation of ATF4 since knockdown of ATF4 partially reversed sorafenib-induced ACHN cell apoptosis. | Sorafenib | activating transcription factor 4 | Homo sapiens |
| 10 | In summary, the present study demonstrates that sorafenib activates ATF4-CHOP-PUMA pathway in RCC cells, resulting in enhanced ER stress-related cell apoptosis. | Sorafenib | activating transcription factor 4 | Homo sapiens |