Pub. Date : 2005 Jun
PMID : 29539150
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Dibutyryl cAMP, a cAMP analog, and forskolin, an adenylate cyclase activator, significantly inhibited IL-1alpha-stimulated MMP-3 production in PDL cells. | Cyclic AMP | interleukin 1 alpha | Homo sapiens |
2 | Dibutyryl cAMP, a cAMP analog, and forskolin, an adenylate cyclase activator, significantly inhibited IL-1alpha-stimulated MMP-3 production in PDL cells. | Cyclic AMP | interleukin 1 alpha | Homo sapiens |
3 | CONCLUSIONS: These data suggest that COX-2-dependent PGE2 downregulates IL-1alpha-elicited MMP-3 production by cAMP-dependent pathways via EP2 /EP4 receptors in human PDL cells. | Cyclic AMP | interleukin 1 alpha | Homo sapiens |