Title : Targeting Hodgkin and Reed-Sternberg Cells with an Inhibitor of Heat-Shock Protein 90: Molecular Pathways of Response and Potential Mechanisms of Resistance.

Pub. Date : 2018 Mar 13

PMID : 29534015






4 Functional Relationships(s)
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1 A proteomic screening identified a total of 262 differentially expressed proteins in sensitive KM-H2 cells and revealed that celastrol"s toxicity involved the suppression of the MAPK/ERK (extracellular signal regulated kinase/mitogen activated protein kinase) pathway. celastrol mitogen-activated protein kinase 3 Homo sapiens
2 A proteomic screening identified a total of 262 differentially expressed proteins in sensitive KM-H2 cells and revealed that celastrol"s toxicity involved the suppression of the MAPK/ERK (extracellular signal regulated kinase/mitogen activated protein kinase) pathway. celastrol mitogen-activated protein kinase 3 Homo sapiens
3 Our results provide the first evidence that celastrol has antitumor effects in cHL cells through the suppression of the MAPK/ERK pathway. celastrol mitogen-activated protein kinase 3 Homo sapiens
4 Our results provide the first evidence that celastrol has antitumor effects in cHL cells through the suppression of the MAPK/ERK pathway. celastrol mitogen-activated protein kinase 3 Homo sapiens