Title : Grb2 and GRAP connect the B cell antigen receptor to Erk MAP kinase activation in human B cells.

Pub. Date : 2018 Mar 9

PMID : 29523808






2 Functional Relationships(s)
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1 Using TALEN-mediated gene targeting, we show that in human B cells Grb2 and GRAP amplify signaling by the immunoglobulin tail tyrosine (ITT) motif of mIgE-containing BCRs and furthermore connect immunoreceptor tyrosine-based activation motif (ITAM) signaling to activation of the Ras-controlled Erk MAP kinase pathway. Tyrosine growth factor receptor bound protein 2 Homo sapiens
2 Using TALEN-mediated gene targeting, we show that in human B cells Grb2 and GRAP amplify signaling by the immunoglobulin tail tyrosine (ITT) motif of mIgE-containing BCRs and furthermore connect immunoreceptor tyrosine-based activation motif (ITAM) signaling to activation of the Ras-controlled Erk MAP kinase pathway. Tyrosine growth factor receptor bound protein 2 Homo sapiens