Protein Name growth factor receptor bound protein 2
Organism Homo sapiens
Gene ID 2885
Gene Symbol


UniProt P62993 (GRB2_HUMAN), B0LPF3 (B0LPF3_HUMAN)
Relationships Total Number of functionally related compound(s) : 283
Total Number of Articles : 662

growth factor receptor bound protein 2

Gene Summary

The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

  • growth factor receptor-bound protein 2
  • HT027
  • SH2/SH3 adapter GRB2
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