Pub. Date : 2018 Mar 9
PMID : 29521261
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Experiments with catalytically inactive Mtmr2, pharmacological blockers of PI(3,5)P2 synthesis, and osmotic stress suggest that Mtmr2-dependent Piezo2 inhibition involves depletion of PI(3,5)P2. | phosphatidyl (3,5) inositol biphosphate | piezo-type mechanosensitive ion channel component 2 | Mus musculus |
| 2 | Experiments with catalytically inactive Mtmr2, pharmacological blockers of PI(3,5)P2 synthesis, and osmotic stress suggest that Mtmr2-dependent Piezo2 inhibition involves depletion of PI(3,5)P2. | phosphatidyl (3,5) inositol biphosphate | piezo-type mechanosensitive ion channel component 2 | Mus musculus |
| 3 | Further, we identified a PI(3,5)P2 binding region in Piezo2, but not Piezo1, that confers sensitivity to Mtmr2 as indicated by functional analysis of a domain-swapped Piezo2 mutant. | phosphatidyl (3,5) inositol biphosphate | piezo-type mechanosensitive ion channel component 2 | Mus musculus |
| 4 | Further, we identified a PI(3,5)P2 binding region in Piezo2, but not Piezo1, that confers sensitivity to Mtmr2 as indicated by functional analysis of a domain-swapped Piezo2 mutant. | phosphatidyl (3,5) inositol biphosphate | piezo-type mechanosensitive ion channel component 2 | Mus musculus |
| 5 | Altogether, our results propose local PI(3,5)P2 modulation via Mtmr2 in the vicinity of Piezo2 as a novel mechanism to dynamically control Piezo2-dependent mechanotransduction in peripheral sensory neurons. | phosphatidyl (3,5) inositol biphosphate | piezo-type mechanosensitive ion channel component 2 | Mus musculus |
| 6 | Altogether, our results propose local PI(3,5)P2 modulation via Mtmr2 in the vicinity of Piezo2 as a novel mechanism to dynamically control Piezo2-dependent mechanotransduction in peripheral sensory neurons. | phosphatidyl (3,5) inositol biphosphate | piezo-type mechanosensitive ion channel component 2 | Mus musculus |