Pub. Date : 2018 Aug 31
PMID : 29500224
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | TLR2 and TLR4 play opposite role in autophagy associated with cisplatin-induced acute kidney injury. | Cisplatin | toll-like receptor 2 | Mus musculus |
| 2 | Hence, the present study aimed to evaluate the specific participation of TLR2 and TLR4 molecules on the development of cisplatin-induced AKI. | Cisplatin | toll-like receptor 2 | Mus musculus |
| 3 | To test the cross-talking between HO-1 and TLRs, hemin (an HO-1 internal inducer) was administrated in cisplatin-treated TLR2 and TLR4 KO mice and it was detected an improvement in the global renal tissue parameters. | Cisplatin | toll-like receptor 2 | Mus musculus |
| 4 | In summary, we documented that TLR2 plays a protective role in cisplatin-induced AKI progression, in part, by a mechanism associated with autophagy up-regulation, considering that its interplay with HO-1 can promote renal tissue recover. | Cisplatin | toll-like receptor 2 | Mus musculus |