Pub. Date : 2018 Jun
PMID : 29493374
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | OBJECTIVE: This study investigated the effect of celastrol on mRNA expression and concentration levels of the pro-inflammatory cytokines tumor necrosis factor alpha (TNFalpha) and interleukin-6 (IL6) that are induced by influenza A/Puerto Rico/8/34 (H1N1; PR8) in Madin-Darby Canine Kidney (MDCK) cells. | celastrol | interleukin 6 | Homo sapiens |
| 2 | RESULTS: mRNA expression and concentrations of TNFalpha and IL6 increased significantly in control virus compared to cell control, and decreased significantly when compared with control virus after celastrol treatment. | celastrol | interleukin 6 | Homo sapiens |
| 3 | CONCLUSION: Due to reducing mRNA expression and concentrations of TNFalpha and IL6, celastrol can serve as a suitable choice to control cytokine-induced inflammation in IAV infection, and therefore it can be used with current antiviral drugs. | celastrol | interleukin 6 | Homo sapiens |