Pub. Date : 2018 Apr 1
PMID : 29486207
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | nAChRs-ERK1/2-Egr-1 signaling participates in the developmental toxicity of nicotine by epigenetically down-regulating placental 11beta-HSD2. | Nicotine | mitogen-activated protein kinase 3 | Homo sapiens |
| 2 | In human BeWo cells, nicotine decreased 11beta-HSD2 expression, increased nAChRalpha9 expression, and activated ERK1/2/Elk-1/Egr-1 signaling in the concentration (0.1-10 muM)-dependent manner. | Nicotine | mitogen-activated protein kinase 3 | Homo sapiens |
| 3 | Antagonism of nAChRs, inhibition of ERK1/2 and Egr-1 knockdown by siRNA were able to block/abrogate the effects of nicotine on histone modification and expression of 11beta-HSD2. | Nicotine | mitogen-activated protein kinase 3 | Homo sapiens |