Pub. Date : 2018 Apr
PMID : 29484434
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | miR-33a-5p enhances the sensitivity of lung adenocarcinoma cells to celastrol by regulating mTOR signaling. | celastrol | mechanistic target of rapamycin kinase | Homo sapiens |
| 2 | Western blot analysis revealed that the expression of mTOR, p-p70S6K and p-4EBP1 decreased following celastrol treatment. | celastrol | mechanistic target of rapamycin kinase | Homo sapiens |
| 3 | These results suggested that mTOR was involved in the mechanism by which miR-33a-5p enhanced the sensitivity of lung adenocarcinoma cells to celastrol. | celastrol | mechanistic target of rapamycin kinase | Homo sapiens |
| 4 | In addition, celastrol upregulated the expression of miR-33a-5p, and high expression of miR-33a-5p inhibited mTOR and its downstream effectors. | celastrol | mechanistic target of rapamycin kinase | Homo sapiens |
| 5 | In summary, miR-33a-5p inhibited the proliferation of lung adenocarcinoma cells, enhanced the antitumor effect of celastrol, and improved sensitivity to celastrol by targeting mTOR in lung adenocarcinoma in vitro and in vivo. | celastrol | mechanistic target of rapamycin kinase | Homo sapiens |