Title : Intact Cell Assays to Monitor AMPK and Determine the Contribution of the AMP-Binding or ADaM Sites to Activation.

Pub. Date : 2018

PMID : 29480480






1 Functional Relationships(s)
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1 We also describe methods to determine whether compounds that activate AMPK in intact cells do so indirectly by interfering with cellular ATP synthesis or directly by binding to AMPK and, if the latter, whether this occurs by binding at the AMP-binding sites on the gamma subunit or at the ADaM site located between the alpha and beta subunits. Adenosine Monophosphate protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens