Title : CD74-ROS1 G2032R mutation transcriptionally up-regulates Twist1 in non-small cell lung cancer cells leading to increased migration, invasion, and resistance to crizotinib.

Pub. Date : 2018 May 28

PMID : 29477381






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 CD74-ROS1 G2032R mutation transcriptionally up-regulates Twist1 in non-small cell lung cancer cells leading to increased migration, invasion, and resistance to crizotinib. Crizotinib twist family bHLH transcription factor 1 Homo sapiens
2 Combination of Twist1 silence and ROS1 inhibitor may provide a potent strategy to treat the ROS1+ NSCLC patients with crizotinib resistance. Crizotinib twist family bHLH transcription factor 1 Homo sapiens