Title : Ghrelin acts centrally to induce an antinociceptive action during colonic distension through the orexinergic, dopaminergic and opioid systems in conscious rats.

Pub. Date : 2018 May 1

PMID : 29476749






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1 These results provide the first evidence that ghrelin acts centrally in the brain to enhance antinociceptive response to colonic distension through the central opioid system, dopamine D2 signaling, and the orexinergic pathway. Dopamine ghrelin and obestatin prepropeptide Rattus norvegicus