Title : Cutting Edge: A New Player in the Alternative Complement Pathway, MASP-1 Is Essential for LPS-Induced, but Not for Zymosan-Induced, Alternative Pathway Activation.

Pub. Date : 2018 Apr 1

PMID : 29475986






2 Functional Relationships(s)
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1 Mannose-lectin binding-associated serine protease (MASP)-1 is known to be the initiator protease of the LP. leucylproline MBL associated serine protease 1 Homo sapiens
2 Using a specific and potent inhibitor of MASP-1, SGMI-1, as well as other MASP-1 inhibitors with different mechanisms of action, we demonstrated that, in addition to its functions in the LP, MASP-1 is essential for bacterial LPS-induced AP activation, whereas it has little effect on zymosan-induced AP activation. leucylproline MBL associated serine protease 1 Homo sapiens