CPRiL

MASP1

MBL associated serine protease 1

This gene encodes a serine protease that functions as a component of the lectin pathway of complement activation. The complement pathway plays an essential role in the innate and adaptive immune response. The encoded protein is synthesized as a zymogen and is activated when it complexes with the pathogen recognition molecules of lectin pathway, the mannose-binding lectin and the ficolins. This protein is not directly involved in complement activation but may play a role as an amplifier of complement activation by cleaving complement C2 or by activating another complement serine protease, MASP-2. The encoded protein is also able to cleave fibrinogen and factor XIII and may may be involved in coagulation. A splice variant of this gene which lacks the serine protease domain functions as an inhibitor of the complement pathway. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2010]

• mannan-binding lectin serine protease 1
• C4/C2 activating component of Ra-reactive factor
• Ra-reactive factor serine protease p100
complement factor MASP-3
complement-activating component of Ra-reactive factor
mannan binding lectin serine peptidase 1
mannose-associated serine protease 1
mannose-binding lectin-associated serine protease 1
mannose-binding protein-associated serine protease
serine protease 5
3MC1
CRARF
CRARF1
MAP-1
MAP1
MASP
MASP-3
MASP3
MAp44
PRSS5
RaRF