Title : Mass Spectrometry-Based Proteomics Reveals Potential Roles of NEK9 and MAP2K4 in Resistance to PI3K Inhibition in Triple-Negative Breast Cancers.

Pub. Date : 2018 May 15

PMID : 29472518






2 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 Knockdown of NEK9 or MAP2K4 reduced both baseline and feedback MAPK/MEK signaling and showed synthetic lethality with buparlisib in vitro A complex in/del frameshift in PIK3CA decreased sensitivity to buparlisib via NEK9/MAP2K4-dependent mechanisms. NVP-BKM120 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Homo sapiens
2 Knockdown of NEK9 or MAP2K4 reduced both baseline and feedback MAPK/MEK signaling and showed synthetic lethality with buparlisib in vitro A complex in/del frameshift in PIK3CA decreased sensitivity to buparlisib via NEK9/MAP2K4-dependent mechanisms. NVP-BKM120 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Homo sapiens