Pub. Date : 2018 Oct
PMID : 29468562
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We firstly observed that the activation of 5-HT1A receptor, but not 5-HT2A receptor, contributed to DM-induced serotonergic behaviors in mice. | Dextromethorphan | 5-hydroxytryptamine (serotonin) receptor 1A | Mus musculus |
| 2 | More importantly, 5-HT1A receptor co-immunoprecipitated PKCdelta in the presence of DM. | Dextromethorphan | 5-hydroxytryptamine (serotonin) receptor 1A | Mus musculus |
| 3 | Our results suggest that interaction between 5-HT1A receptor and PKCdelta is critical for inducing DM-induced serotonergic behaviors and that inhibition of PKCdelta attenuates the serotonergic behaviors via downregulation of 5-HT1A receptor and upregulation of Nrf2-dependent GSH synthesis. | Dextromethorphan | 5-hydroxytryptamine (serotonin) receptor 1A | Mus musculus |
| 4 | Our results suggest that interaction between 5-HT1A receptor and PKCdelta is critical for inducing DM-induced serotonergic behaviors and that inhibition of PKCdelta attenuates the serotonergic behaviors via downregulation of 5-HT1A receptor and upregulation of Nrf2-dependent GSH synthesis. | Dextromethorphan | 5-hydroxytryptamine (serotonin) receptor 1A | Mus musculus |