Pub. Date : 2018 Feb 20
PMID : 29463776
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We found that the nonreceptor tyrosine kinases Abl and Arg (Abl/Arg) promoted the secretion of cathepsin B and cathepsin L by activating transcription factors (namely, Ets1, Sp1, and NF-kappaB/p65) that have key roles in the epithelial-mesenchymal transition (EMT), invasion, and therapeutic resistance. | Arginine | ABL proto-oncogene 1, non-receptor tyrosine kinase | Homo sapiens |
| 2 | We found that the nonreceptor tyrosine kinases Abl and Arg (Abl/Arg) promoted the secretion of cathepsin B and cathepsin L by activating transcription factors (namely, Ets1, Sp1, and NF-kappaB/p65) that have key roles in the epithelial-mesenchymal transition (EMT), invasion, and therapeutic resistance. | Arginine | ABL proto-oncogene 1, non-receptor tyrosine kinase | Homo sapiens |
| 3 | We found that the nonreceptor tyrosine kinases Abl and Arg (Abl/Arg) promoted the secretion of cathepsin B and cathepsin L by activating transcription factors (namely, Ets1, Sp1, and NF-kappaB/p65) that have key roles in the epithelial-mesenchymal transition (EMT), invasion, and therapeutic resistance. | Arginine | ABL proto-oncogene 1, non-receptor tyrosine kinase | Homo sapiens |
| 4 | In some melanoma cell lines, Abl/Arg promoted the Ets1/p65-induced secretion of cathepsin B and cathepsin L in a kinase-independent manner, whereas in other melanoma lines, Abl/Arg promoted the kinase-dependent, Sp1/Ets1/p65-mediated induction of cathepsin L secretion and the Sp1/p65-mediated induction of cathepsin B secretion. | Arginine | ABL proto-oncogene 1, non-receptor tyrosine kinase | Homo sapiens |
| 5 | As an indication of clinical relevance, the abundance of mRNAs encoding Abl/Arg, Sp1, Ets1, and cathepsins was positively correlated in primary melanomas, and Abl/Arg-driven invasion in culture and metastasis in vivo required cathepsin secretion. | Arginine | ABL proto-oncogene 1, non-receptor tyrosine kinase | Homo sapiens |
| 6 | As an indication of clinical relevance, the abundance of mRNAs encoding Abl/Arg, Sp1, Ets1, and cathepsins was positively correlated in primary melanomas, and Abl/Arg-driven invasion in culture and metastasis in vivo required cathepsin secretion. | Arginine | ABL proto-oncogene 1, non-receptor tyrosine kinase | Homo sapiens |
| 7 | As an indication of clinical relevance, the abundance of mRNAs encoding Abl/Arg, Sp1, Ets1, and cathepsins was positively correlated in primary melanomas, and Abl/Arg-driven invasion in culture and metastasis in vivo required cathepsin secretion. | Arginine | ABL proto-oncogene 1, non-receptor tyrosine kinase | Homo sapiens |