Title : Apoptosis of enterocytes and nitration of junctional complex proteins promote alcohol-induced gut leakiness and liver injury.

Pub. Date : 2018 Jul

PMID : 29458168






2 Functional Relationships(s)
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1 The levels of intestinal CYP2E1, iNOS, nitrated proteins and apoptosis-related marker proteins were significantly elevated in binge alcohol-exposed rodents. Alcohols cytochrome P450 family 2 subfamily E member 1 Homo sapiens
2 Additionally, pretreatment with specific inhibitors of CYP2E1 and iNOS prevented disorganization and/or degradation of TJ proteins in alcohol-exposed T84 colonic cells. Alcohols cytochrome P450 family 2 subfamily E member 1 Homo sapiens