Pub. Date : 2018 Apr
PMID : 29453896
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Antimalarial drug mefloquine inhibits nuclear factor kappa B signaling and induces apoptosis in colorectal cancer cells. | Mefloquine | nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 | Mus musculus |
| 2 | In the present study, we found that the widely used antimalarial drug mefloquine was a NF-kappaB inhibitor that blocked the activation of IkappaBalpha kinase, leading to reduction of IkappaBalpha degradation, decrease of p65 phosphorylation, and suppressed expression of NF-kappaB target genes in CRC cells. | Mefloquine | nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 | Mus musculus |
| 3 | In the present study, we found that the widely used antimalarial drug mefloquine was a NF-kappaB inhibitor that blocked the activation of IkappaBalpha kinase, leading to reduction of IkappaBalpha degradation, decrease of p65 phosphorylation, and suppressed expression of NF-kappaB target genes in CRC cells. | Mefloquine | nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 | Mus musculus |
| 4 | These results showed that mefloquine could exert antitumor action through inhibiting the NF-kappaB signaling pathway, and indicated that the antimalarial drug might be repurposed for anti-CRC therapy in the clinic as a single agent or in combination with other anticancer drugs. | Mefloquine | nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 | Mus musculus |