Title : Integration of Distinct ShcA Signaling Complexes Promotes Breast Tumor Growth and Tyrosine Kinase Inhibitor Resistance.

Pub. Date : 2018 May

PMID : 29453318






1 Functional Relationships(s)
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Protein Name
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1 Receptor tyrosine kinases (RTK), such as ErbB2, bind the ShcA PTB domain to promote breast tumorigenesis by engaging Grb2 downstream of the ShcA tyrosine phosphorylation sites to activate AKT/mTOR signaling. Tyrosine growth factor receptor bound protein 2 Homo sapiens