Pub. Date : 2018
PMID : 29449801
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Lithium, a clinically relevant drug commonly prescribed as a mood stabilizer for psychiatric disorders, significantly increased levels of phosphorylated GSK3beta serine 9, an inhibitory phosphorylation site, and decreased beta-catenin ser33/37/thr41 phosphorylation in vitro, indicating GSK3beta inhibition and reduced beta-catenin degradation. | Serine | glycogen synthase kinase 3 beta | Homo sapiens |
| 2 | Similar alterations were also demonstrated in vivo; lithium administration increased GSK3beta serine 9 phosphorylation and GluN2A levels, suggesting a reduced GSK3beta activity and augmented GluN2A expression. | Serine | glycogen synthase kinase 3 beta | Homo sapiens |