Pub. Date : 2018 Jul
PMID : 29448836
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Newborn UGT1 KO mice treated with AAV had serum total bilirubin levels that were 5.7 times higher than the levels seen in heterozygous and wild-type mice, likely due to dilution of vector genome copies (GC) in the liver resulting from a proliferation of hepatocytes during growth of the animal. | Bilirubin | UDP glucuronosyltransferase 1 family, polypeptide A2 | Mus musculus |
| 2 | The elevation in serum total bilirubin levels in adult UGT1 KO mice depended on the AAV8 vector dose. | Bilirubin | UDP glucuronosyltransferase 1 family, polypeptide A2 | Mus musculus |
| 3 | Therefore, a low-level and likely transient decrease in serum total bilirubin during the first days of life is necessary for rescuing the lethal phenotype present in the neonatal UGT1 KO mouse. | Bilirubin | UDP glucuronosyltransferase 1 family, polypeptide A2 | Mus musculus |