Title : Pirh2 mediates the sensitivity of myeloma cells to bortezomib via canonical NF-κB signaling pathway.

Pub. Date : 2018 Sep

PMID : 29441489






1 Functional Relationships(s)
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1 Therefore, Pirh2 suppressed the canonical NF-kappaB signaling pathway by inhibiting the phosphorylation and subsequent degradation of IKBa to overcome acquired bortezomib resistance in MM cells. Bortezomib NFKB inhibitor alpha Homo sapiens