Title : Targeting the cMET pathway augments radiation response without adverse effect on hearing in NF2 schwannoma models.

Pub. Date : 2018 Feb 27

PMID : 29440379






4 Functional Relationships(s)
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1 Using this model, we discovered that cMET blockade by crizotinib (CRZ) enhanced schwannoma radiosensitivity by enhancing DNA damage, and CRZ treatment combined with low-dose radiation was as effective as high-dose radiation. Crizotinib met proto-oncogene Mus musculus
2 Using this model, we discovered that cMET blockade by crizotinib (CRZ) enhanced schwannoma radiosensitivity by enhancing DNA damage, and CRZ treatment combined with low-dose radiation was as effective as high-dose radiation. Crizotinib met proto-oncogene Mus musculus
3 This cMET gene knockdown study independently confirmed the role of the cMET pathway in mediating the effect of CRZ. Crizotinib met proto-oncogene Mus musculus
4 This cMET gene knockdown study independently confirmed the role of the cMET pathway in mediating the effect of CRZ. Crizotinib met proto-oncogene Mus musculus