Pub. Date : 2018 Apr
PMID : 29436680
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Curcumin increases cholesterol efflux via heme oxygenase-1-mediated ABCA1 and SR-BI expression in macrophages. | Curcumin | heme oxygenase 1 | Homo sapiens |
| 2 | Additionally, curcumin significantly upregulated HO-1 expression. | Curcumin | heme oxygenase 1 | Homo sapiens |
| 3 | HO-1 small interfering (si)RNA partly abolished the increased SR-BI and ABCA1 expression induced by curcumin. | Curcumin | heme oxygenase 1 | Homo sapiens |
| 4 | Nrf2 siRNA successfully inhibited the curcumin-induced HO-1 expression. | Curcumin | heme oxygenase 1 | Homo sapiens |
| 5 | Overall, these data indicated that curcumin activates the Nrf2-ARE signaling pathway and upregulates HO-1 expression, which mediates SR-BI and ABCA1 expression and thereby increases cholesterol efflux. | Curcumin | heme oxygenase 1 | Homo sapiens |