Pub. Date : 2018 Feb
PMID : 29434958
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Anticancer effects of 10-hydroxycamptothecin induce apoptosis of human osteosarcoma through activating caspase-3, p53 and cytochrome c pathways. | 10-hydroxycamptothecin | tumor protein p53 | Homo sapiens |
| 2 | The anticancer effects of HCPT were demonstrated to significantly activate the protein expression of p53, PARP-1 and cytochrome c, and suppress Bcl-2 protein expression and promote the activity of caspase-9 and caspase-3 in human osteosarcoma cells. | 10-hydroxycamptothecin | tumor protein p53 | Homo sapiens |
| 3 | In conclusion, the anticancer effects of HCPT appear to induce the apoptosis of human osteosarcoma cells through the activation of the caspase-3, p53 and cytochrome c pathways. | 10-hydroxycamptothecin | tumor protein p53 | Homo sapiens |