Title : DOCK1 inhibition suppresses cancer cell invasion and macropinocytosis induced by self-activating Rac1P29S mutation.

Pub. Date : 2018 Feb 26

PMID : 29432733






2 Functional Relationships(s)
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1 We found that the catalytic domain of DOCK1, a Rac-specific guanine nucleotide exchange factor (GEF) implicated in malignancy of a variety of cancers, can greatly accelerate the GDP/GTP exchange of Rac1P29S. Guanosine Diphosphate Ras protein specific guanine nucleotide releasing factor 1 Homo sapiens
2 We found that the catalytic domain of DOCK1, a Rac-specific guanine nucleotide exchange factor (GEF) implicated in malignancy of a variety of cancers, can greatly accelerate the GDP/GTP exchange of Rac1P29S. Guanosine Diphosphate Ras protein specific guanine nucleotide releasing factor 1 Homo sapiens