Title : 14, 15-EET induces breast cancer cell EMT and cisplatin resistance by up-regulating integrin αvβ3 and activating FAK/PI3K/AKT signaling.

Pub. Date : 2018 Feb 9

PMID : 29426357






2 Functional Relationships(s)
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1 Furthermore, we find that 14, 15-EET induces breast cancer cells EMT and cisplatin resistance in vivo, alphavbeta3 integrin and the resulting FAK/PI3K/AKT signaling pathway are responsible for 14, 15-EET induced-breast cancer cells cisplatin resistance. Cisplatin protein tyrosine kinase 2 Homo sapiens
2 CONCLUSIONS: Our findings suggest that inhibition of 14, 15-EET or inactivation of integrin alphavbeta3/FAK/PI3K/AKT pathway could serve as a novel approach to reverse EMT and cisplatin resistance in breast cancer cells. Cisplatin protein tyrosine kinase 2 Homo sapiens