Title : mRNA-Independent way to regulate translation elongation rate in eukaryotic cells.

Pub. Date : 2018 Mar

PMID : 29417736






4 Functional Relationships(s)
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1 We hypothesize that the exit rate of eukaryotic translation elongation factor 1A (eEF1A)*GDP from the 80S ribosome depends on the protein affinity to specific aminoacyl-tRNA remaining on the ribosome after GTP hydrolysis. Guanosine Diphosphate eukaryotic translation elongation factor 1 alpha 1 Homo sapiens
2 We hypothesize that the exit rate of eukaryotic translation elongation factor 1A (eEF1A)*GDP from the 80S ribosome depends on the protein affinity to specific aminoacyl-tRNA remaining on the ribosome after GTP hydrolysis. Guanosine Diphosphate eukaryotic translation elongation factor 1 alpha 1 Homo sapiens
3 Subsequently, a slower dissociation of eEF1A*GDP from certain aminoacyl-tRNAs in the ribosome can negatively influence the ribosomal elongation rate in a tRNA-dependent and mRNA-independent way. Guanosine Diphosphate eukaryotic translation elongation factor 1 alpha 1 Homo sapiens
4 The specific tRNA-dependent departure rate of eEF1A*GDP from the ribosome is suggested to be a novel factor contributing to the overall translation elongation control in eukaryotic cells. Guanosine Diphosphate eukaryotic translation elongation factor 1 alpha 1 Homo sapiens