Pub. Date : 2018 Jan 5
PMID : 29416762
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Metformin synergistically suppress tumor growth with doxorubicin and reverse drug resistance by inhibiting the expression and function of P-glycoprotein in MCF7/ADR cells and xenograft models. | Metformin | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 2 | Metformin increased nuclear doxorubicin accumulation and overcame drug resistance by down-regulating drug-resistant genes such as P-glycoprotein (Pgp). | Metformin | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 3 | Metformin increased nuclear doxorubicin accumulation and overcame drug resistance by down-regulating drug-resistant genes such as P-glycoprotein (Pgp). | Metformin | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 4 | In addition, metformin suppressed Pgp expression in vivo. | Metformin | ATP binding cassette subfamily B member 1 | Homo sapiens |