Title : MicroRNA-365 alleviates morphine analgesic tolerance via the inactivation of the ERK/CREB signaling pathway by negatively targeting β-arrestin2.

Pub. Date : 2018 Feb 7

PMID : 29415719






1 Functional Relationships(s)
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1 RESULTS: The results obtained showed that when compared with the morphine tolerance group, there was an increase in miR-365 expression and a decrease in the beta-arrestin2, ERK, CREB protein expressions, contents of IL-1beta, TNF-alpha, IL-18 and GFAP expression in the miR-365 mimic group, while the miR-365 inhibitor group displayed an opposite trend. Morphine tumor necrosis factor Rattus norvegicus