Pub. Date : 2018 Apr
PMID : 29396886
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Antitumor effects of metformin are a result of inhibiting nuclear factor kappa B nuclear translocation in esophageal squamous cell carcinoma. | Metformin | nuclear factor kappa B subunit 1 | Homo sapiens |
| 2 | We found that localization of NF-kappaB in the nucleus was reduced after metformin treatment. | Metformin | nuclear factor kappa B subunit 1 | Homo sapiens |
| 3 | This suggests that metformin inhibited the activation of NF-kappaB. | Metformin | nuclear factor kappa B subunit 1 | Homo sapiens |
| 4 | In conclusion, metformin showed multiple antitumor effects such as growth suppression, invasion inhibition, and control of EMT by inhibiting NF-kappaB localization on ESCC. | Metformin | nuclear factor kappa B subunit 1 | Homo sapiens |