Pub. Date : 2018 May 1
PMID : 29385411
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In addition, high PA levels reduced the expression of Sirtuin 3 (SIRT3) and phosphorylated AMP-activated protein kinase (AMPK), while the AMPK activator, AICAR, restored mitochondrial function as well as oocyte ability and reduced the acetylation of mitochondrial protein. | Palmitic Acid | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |
| 2 | In addition, high PA levels reduced the expression of Sirtuin 3 (SIRT3) and phosphorylated AMP-activated protein kinase (AMPK), while the AMPK activator, AICAR, restored mitochondrial function as well as oocyte ability and reduced the acetylation of mitochondrial protein. | Palmitic Acid | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |
| 3 | Our results indicated that PA induces ceramide accumulation and downregulates the AMPK/SIRT3 pathway causing mitochondrial protein hyperacetylation and dysfunction in oocytes. | Palmitic Acid | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |