Title : Effect of Melatonin on the Renin-Angiotensin-Aldosterone System in l-NAME-Induced Hypertension.

Pub. Date : 2018 Jan 29

PMID : 29382124






3 Functional Relationships(s)
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1 The serum concentration of angiotensin (Ang) 1-8 (Ang II) and its downstream metabolites were reduced in the l-NAME group and remained unaltered by melatonin. NG-Nitroarginine Methyl Ester angiotensinogen Rattus norvegicus
2 The serum aldosterone level and its ratio to Ang II (AA2-ratio) were increased in the l-NAME group without being modified by melatonin. NG-Nitroarginine Methyl Ester angiotensinogen Rattus norvegicus
3 We conclude that l-NAME-hypertension is associated with reduced level of Ang II and its downstream metabolites and increased aldosterone concentration and AA2-ratio. NG-Nitroarginine Methyl Ester angiotensinogen Rattus norvegicus