Pub. Date : 2017 Oct-Dec
PMID : 29362600
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Palmitate-induced insulin resistance is attenuated by Pioglitazone and EGCG through reducing the gluconeogenic key enzymes expression in HepG2 cells. | epigallocatechin gallate | insulin | Homo sapiens |
| 2 | Combined treatment of insulin-resistant cells with EGCG and pioglitazone significantly decreased the mRNA level of PEPCK and G6Pase by 73 and 80%, respectively. | epigallocatechin gallate | insulin | Homo sapiens |
| 3 | When the insulin resistant HepG2 cells were treated alone with EGCG and pioglitazone, the glucose production reduced by 50 and 55%, respectively. | epigallocatechin gallate | insulin | Homo sapiens |
| 4 | CONCLUSIONS: These data suggest the additive inhibitory effect of co-treatment with pioglitazone and EGCG on the gluconeogenesis pathway in palmitate-induced insulin resistance HepG2 cells. | epigallocatechin gallate | insulin | Homo sapiens |