Pub. Date : 2018 May
PMID : 29353218
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Sulforaphane prevents angiotensin II-induced cardiomyopathy by activation of Nrf2 via stimulating the Akt/GSK-3ss/Fyn pathway. | sulforaphane | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | Mus musculus |
| 2 | METHODS AND RESULTS: Administration of a subpressor dose of Ang II to wild-type mice induced cardiac oxidative stress, inflammation, remodeling and dysfunction, all of which could be prevented by SFN treatment with Nrf2 up-regulation and activation. | sulforaphane | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | Mus musculus |
| 3 | Meanwhile, the ability of SFN to protect against Ang II-induced cardiac damage was lost in Nrf2-KO mice. | sulforaphane | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | Mus musculus |