Pub. Date : 2018 Jun
PMID : 29350822
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Resveratrol Suppresses Rotenone-induced Neurotoxicity Through Activation of SIRT1/Akt1 Signaling Pathway. | Resveratrol | AKT serine/threonine kinase 1 | Rattus norvegicus |
| 2 | Moreover, resveratrol reversed rotenone-induced decrease in SIRT1 expression and Akt1 phosphorylation (P < 0.05). | Resveratrol | AKT serine/threonine kinase 1 | Rattus norvegicus |
| 3 | Furthermore, when the SIRT1 and Akt1 activity was inhibited by niacinamide and LY294002, respectively, the neuroprotective effect of resveratrol was remarkably attenuated, which implied that SIRT1 and Akt1 could mediate this process and may be potential molecular targets for intervening rotenone-induced neurotoxicity. | Resveratrol | AKT serine/threonine kinase 1 | Rattus norvegicus |
| 4 | Furthermore, when the SIRT1 and Akt1 activity was inhibited by niacinamide and LY294002, respectively, the neuroprotective effect of resveratrol was remarkably attenuated, which implied that SIRT1 and Akt1 could mediate this process and may be potential molecular targets for intervening rotenone-induced neurotoxicity. | Resveratrol | AKT serine/threonine kinase 1 | Rattus norvegicus |
| 5 | In summary, our study demonstrated that resveratrol reduced rotenone-induced oxidative damage, which was partly mediated through activation of the SIRT1/Akt1 signaling pathway. | Resveratrol | AKT serine/threonine kinase 1 | Rattus norvegicus |