Pub. Date : 2018 Jan 17
PMID : 29343688
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Wee1 inhibitor MK1775 sensitizes KRAS mutated NSCLC cells to sorafenib. | Sorafenib | WEE1 G2 checkpoint kinase | Homo sapiens |
| 2 | To overcome this resistance, we used high-throughput screening with a siRNA library directed against 719 human kinases, and Wee1 was selected as a sorafenib response modulator. | Sorafenib | WEE1 G2 checkpoint kinase | Homo sapiens |
| 3 | Inhibition of Wee1 by its specific inhibitor MK1775 in combination with sorafenib restored the KRAS mutated cells" response to the multi-target tyrosine kinase inhibitor. | Sorafenib | WEE1 G2 checkpoint kinase | Homo sapiens |