Title : Membrane Allostery and Unique Hydrophobic Sites Promote Enzyme Substrate Specificity.

Pub. Date : 2018 Mar 7

PMID : 29342349






1 Functional Relationships(s)
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1 Molecular dynamics simulations revealed the optimal phospholipid binding mode leading to a detailed understanding of the preference of cytosolic phospholipase A2 for cleavage of proinflammatory arachidonic acid, calcium-independent phospholipase A2, which is involved in membrane remodeling for cleavage of linoleic acid and for antibacterial secreted phospholipase A2 favoring linoleic acid, saturated fatty acids, and phosphatidylglycerol. Fatty Acids phospholipase A2 group IB Homo sapiens