Title : What Gives an Insulin Hexamer Its Unique Shape and Stability? Role of Ten Confined Water Molecules.

Pub. Date : 2018 Feb 8

PMID : 29341613






1 Functional Relationships(s)
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1 We combine molecular dynamics simulations, quantum calculations, and X-ray analyses to discover that a team of approximately 10 water molecules confined inside a barrel-shaped nanocavity at the center of insulin hexamer is one of the major causes that account for the unusual stability of the biomolecular assembly. Water insulin Homo sapiens