Title : In vitro anti-diabetic effect of flavonoids and pheophytins from Allophylus cominia Sw. on the glucose uptake assays by HepG2, L6, 3T3-L1 and fat accumulation in 3T3-L1 adipocytes.

Pub. Date : 2018 Apr 24

PMID : 29339110






3 Functional Relationships(s)
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1 On HepG2 cells Insulin EC50 of 93 +- 21nM decreased to 13 +- 2nM in the presence of the flavonoids mixture from A.cominia. Flavonoids insulin Homo sapiens
2 In L6 cells, insulin also produced a concentration-dependent increase with an EC50 of 28.6 +- 0.7nM; EC50 decreased to 0.08 +- 0.02nM and 5 +- 0.9nM in the presence of 100mug/ml of flavonoids and pheophytins mixtures, respectively. Flavonoids insulin Homo sapiens
3 In 3T3-L1 fibroblasts, insulin had an EC50 of >1000nM that decreased to 38 +- 4nM in the presence of the flavonoids extract. Flavonoids insulin Homo sapiens