Pub. Date : 2018 Mar
PMID : 29328389
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | miR-375 inhibits IFN-gamma-induced programmed death 1 ligand 1 surface expression in head and neck squamous cell carcinoma cells by blocking JAK2/STAT1 signaling. | mir-375 | CD274 molecule | Sus scrofa |
| 2 | In the present study, we investigated the effects of miR-375 on PD-L1 expression in head and neck squamous cell carcinoma (HNSCC) cells by qRT-PCR and western blot analyses. | mir-375 | CD274 molecule | Sus scrofa |
| 3 | We confirmed that miR-375 inhibited IFN-gamma-induced PD-L1 surface expression in HNSCC cells, and we observed that Janus kinase 2 (JAK2) is a bona fide target of miR-375 and further activated signal transducer and activator of transcription 1 (STAT1). | mir-375 | CD274 molecule | Sus scrofa |
| 4 | We confirmed that miR-375 inhibited IFN-gamma-induced PD-L1 surface expression in HNSCC cells, and we observed that Janus kinase 2 (JAK2) is a bona fide target of miR-375 and further activated signal transducer and activator of transcription 1 (STAT1). | mir-375 | CD274 molecule | Sus scrofa |
| 5 | Additionally, miR-375-mediated inhibition of PD-L1 expression was dependent on the JAK2/STAT1 pathway. | mir-375 | CD274 molecule | Sus scrofa |
| 6 | Therefore, by attenuating PD-1/PD-L1 signaling, miR-375 may also serve as a modulator to increase the cell immune responses to HNSCC. | mir-375 | CD274 molecule | Sus scrofa |