Title : Structural Insight into the Discrimination between 8-Oxoguanine Glycosidic Conformers by DNA Repair Enzymes: A Molecular Dynamics Study of Human Oxoguanine Glycosylase 1 and Formamidopyrimidine-DNA Glycosylase.

Pub. Date : 2018 Feb 20

PMID : 29320630






3 Functional Relationships(s)
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1 hOgg1 and FPG are the primary DNA repair enzymes responsible for removing the major guanine (G) oxidative product, namely, 7,8-dihydro-8-oxoguanine (OG), in humans and bacteria, respectively. 7,8-dihydro-8-oxoguanine 8-oxoguanine DNA glycosylase Homo sapiens
2 hOgg1 and FPG are the primary DNA repair enzymes responsible for removing the major guanine (G) oxidative product, namely, 7,8-dihydro-8-oxoguanine (OG), in humans and bacteria, respectively. 7,8-dihydro-8-oxoguanine 8-oxoguanine DNA glycosylase Homo sapiens
3 As a first step toward understanding this difference in activity, we have employed molecular dynamics simulations to examine how the anti and syn conformers of OG are accommodated in the hOgg1 and FPG active sites. 7,8-dihydro-8-oxoguanine 8-oxoguanine DNA glycosylase Homo sapiens