Title : Lipopolysaccharide-induced inflammation in monocytes/macrophages is blocked by liposomal delivery of Gi-protein inhibitor.

Pub. Date : 2018

PMID : 29317816






2 Functional Relationships(s)
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1 Materials and methods: Guanosine 5"-O-(2-thiodiphosphate) (GOT), a guanosine diphosphate analog that completely inhibits G-protein activation by guanosine triphosphate and its analogs, was encapsulated into liposomes and tested for anti-inflammatory effects in LPS-activated THP1 monocytes or THP1-derived macrophages. guanosine 5'-O-(2-thiodiphosphate) GLI family zinc finger 2 Homo sapiens
2 Materials and methods: Guanosine 5"-O-(2-thiodiphosphate) (GOT), a guanosine diphosphate analog that completely inhibits G-protein activation by guanosine triphosphate and its analogs, was encapsulated into liposomes and tested for anti-inflammatory effects in LPS-activated THP1 monocytes or THP1-derived macrophages. guanosine 5'-O-(2-thiodiphosphate) GLI family zinc finger 2 Homo sapiens