Title : Azemiopsin, a Selective Peptide Antagonist of Muscle Nicotinic Acetylcholine Receptor: Preclinical Evaluation as a Local Muscle Relaxant.

Pub. Date : 2018 Jan 7

PMID : 29316656






3 Functional Relationships(s)
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Protein Name
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1 The peptide effectively inhibited (IC50 ~ 19 nM) calcium response of muscle nAChR evoked by 30 muM (EC100) acetylcholine but was less potent (IC50 ~ 3 muM) at alpha7 nAChR activated by 10 muM (EC50) acetylcholine and had a low affinity to alpha4beta2 and alpha3-containing nAChR, as well as to GABAA or 5HT3 receptors. Calcium cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus
2 The peptide effectively inhibited (IC50 ~ 19 nM) calcium response of muscle nAChR evoked by 30 muM (EC100) acetylcholine but was less potent (IC50 ~ 3 muM) at alpha7 nAChR activated by 10 muM (EC50) acetylcholine and had a low affinity to alpha4beta2 and alpha3-containing nAChR, as well as to GABAA or 5HT3 receptors. Calcium cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus
3 The peptide effectively inhibited (IC50 ~ 19 nM) calcium response of muscle nAChR evoked by 30 muM (EC100) acetylcholine but was less potent (IC50 ~ 3 muM) at alpha7 nAChR activated by 10 muM (EC50) acetylcholine and had a low affinity to alpha4beta2 and alpha3-containing nAChR, as well as to GABAA or 5HT3 receptors. Calcium cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus