Title : Pathological role of lipid interaction with α-synuclein in Parkinson's disease.

Pub. Date : 2018 Oct

PMID : 29305919






2 Functional Relationships(s)
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1 Furthermore, genetic and clinicopathological studies have revealed mutations in the glucocerebrosidase 1 (GBA1) gene, which encodes a degrading enzyme for the glycolipid glucosylceramide (GlcCer), as strong risk factors for PD and DLB, and we recently demonstrated that GlcCer promotes toxic conversion of alphaSyn. Glucosylceramides synuclein alpha Homo sapiens
2 Furthermore, genetic and clinicopathological studies have revealed mutations in the glucocerebrosidase 1 (GBA1) gene, which encodes a degrading enzyme for the glycolipid glucosylceramide (GlcCer), as strong risk factors for PD and DLB, and we recently demonstrated that GlcCer promotes toxic conversion of alphaSyn. Glucosylceramides synuclein alpha Homo sapiens