Pub. Date : 2018 Jan
PMID : 29304533
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Sphingosine-1-phosphate (S1P) is a potent lipid mediator released from activated platelets by an adenosine triphosphate (ATP)-dependent export mechanism. | Adenosine Triphosphate | sphingosine-1-phosphate receptor 1 | Mus musculus |
| 2 | Sphingosine-1-phosphate (S1P) is a potent lipid mediator released from activated platelets by an adenosine triphosphate (ATP)-dependent export mechanism. | Adenosine Triphosphate | sphingosine-1-phosphate receptor 1 | Mus musculus |
| 3 | Transport studies in membrane vesicles of Sf9 cells containing recombinant human MRP4 revealed that MRP4 mediates ATP-dependent transport of fluorescein- and tritium-labelled S1P. | Adenosine Triphosphate | sphingosine-1-phosphate receptor 1 | Mus musculus |
| 4 | Also, ATP-dependent S1P transport in platelet membrane vesicles containing endogenous MRP4 was inhibited by the MRP inhibitor MK571 and the MRP4-selective compound Ceefourin-1. | Adenosine Triphosphate | sphingosine-1-phosphate receptor 1 | Mus musculus |
| 5 | Fluvastatin and rosuvastatin interfered with MRP4 function inhibiting ATP-dependent cGMP (cyclic guanosine monophosphate) uptake into MRP4-containing vesicles, inhibited MRP4-mediated S1P transport in vitro and significantly attenuated endogenous S1P release from agonist-activated platelet ex vivo. | Adenosine Triphosphate | sphingosine-1-phosphate receptor 1 | Mus musculus |
| 6 | Fluvastatin and rosuvastatin interfered with MRP4 function inhibiting ATP-dependent cGMP (cyclic guanosine monophosphate) uptake into MRP4-containing vesicles, inhibited MRP4-mediated S1P transport in vitro and significantly attenuated endogenous S1P release from agonist-activated platelet ex vivo. | Adenosine Triphosphate | sphingosine-1-phosphate receptor 1 | Mus musculus |