Pub. Date : 2018 Feb 6
PMID : 29283561
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | However, the subsequent 17,20 carbon-carbon scission reaction displays variable substrate specificity in the numerous CYP17A1 isozymes operating in vertebrates, manifesting as different Kd and kcat values when presented with 17alpha-hydroxypregnenlone (OHPREG) versus 17alpha-hydroxyprogesterone (OHPROG). | ohpreg | cytochrome P450 family 17 subfamily A member 1 | Homo sapiens |
| 2 | Here we show that the identity of the residue at position 202 in human CYP17A1, thought to form a hydrogen bond with the A-ring alcohol substituent on the pregnene- nucleus, is a key driver of this enzyme"s native preference for OHPREG. | ohpreg | cytochrome P450 family 17 subfamily A member 1 | Homo sapiens |
| 3 | Replacement of asparagine 202 with serine completely reverses the preference of CYP17A1, more than doubling the rate of turnover of the OHPROG to androstenedione reaction and substantially decreasing the rate of formation of dehydroepiandrosterone from OHPREG. | ohpreg | cytochrome P450 family 17 subfamily A member 1 | Homo sapiens |