Title : Wild type Kirsten rat sarcoma is a novel microRNA-622-regulated therapeutic target for hepatocellular carcinoma and contributes to sorafenib resistance.

Pub. Date : 2018 Jul

PMID : 29275358






3 Functional Relationships(s)
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1 Sorafenib-resistant HCC cells showed elevated KRAS expression, and KRAS inhibition resensitised sorafenib-resistant cells to suppression of proliferation and induction of apoptosis. Sorafenib KRAS proto-oncogene, GTPase Rattus norvegicus
2 Sorafenib-resistant HCC cells showed elevated KRAS expression, and KRAS inhibition resensitised sorafenib-resistant cells to suppression of proliferation and induction of apoptosis. Sorafenib KRAS proto-oncogene, GTPase Rattus norvegicus
3 CONCLUSIONS: KRAS is dysregulated in HCC by loss of tumour-suppressive microRNA-622, contributing to tumour progression, sorafenib sensitivity and resistance. Sorafenib KRAS proto-oncogene, GTPase Rattus norvegicus